Our services

The high versatility of modeling skills represented within M&S Decisions allows us to cover: population PKPD and pharmacometrics, quantitative systems pharmacology (QSP), disease progression modeling, meta-analyses – thereby providing our clients with quantitative companion tools, in support of decision-making across Drug R&D continuum.

M&S Decisions modeling skills

Pharmacometrics

  • Population pharmacokinetic and pharmacodynamic (PKPD) modeling, Dose-Exposure-Response analysis, population disease progression modeling, time-to-event and categorical data analysis, longitudinal modeling and clinical trial simulations;

  • Meta-analyses and advanced data mining.

Quantitative Systems pharmacology / mechanistic modeling

  • Target turnover models, target-mediated disposition models, mechanistic disease progression modeling;

  • Physiologically-based pharmacokinetic (PBPK) modeling;

  • Systems biology modeling: cellular pathway and signal transduction models, biomarker identification aided by context modeling, gene regulatory network models;

  • Cell dynamics modeling: cell growth and cell death modeling (bacteria, viruses, tumors), cell cycle and circadian rhythm modeling.

Cost-effectiveness modeling, health outcome research and disease burden assessment, decision analysis