The high versatility of modeling skills represented within the M&S Decisions allow us to cover: population PKPD and pharmacometrics, quantitative systems pharmacology (QSP), disease progression modeling, meta-analyses – thereby providing our clients with quantitative companion tools, in support of decision-making across the Drug R&D continuum.
M&S Decisions modeling skills
Population pharmacokinetic and pharmacodynamic (PKPD) modeling, Dose-Exposure-Response analysis, population disease progression modeling, time-to-event and categorical data analysis, longitudinal modeling and clinical trial simulations;
Meta-analyses and advanced data mining.
Quantitative Systems pharmacology / mechanistic modeling
Target turnover models, target-mediated disposition models, mechanistic disease progression modeling;
Physiologically-based pharmacokinetic (PBPK) modeling;
Systems biology modeling: cellular pathway and signal transduction models, biomarker identification aided by context modeling, gene regulatory network models;
Cell dynamics modeling: cell growth and cell death modeling (bacteria, viruses, tumors), cell cycle and circadian rhythm modeling.